منابع مشابه
Circulating MicroRNAs in cardiovascular disease.
MicroRNAs (miRNAs) are short, single-stranded, noncoding, highly conserved posttranscriptional regulators found in a variety of tissues including circulating blood.1 MicroRNAs regulate gene expression posttranscriptionally through inhibiting translation from and/or inducing degradation of specific RNAs.2 Certain miRNAs are expressed and function cell-type specifically or in association with par...
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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play a key role in the pathogenesis of autoimmune and gastrointestinal diseases. Previous studies have revealed that miRNAs are dysregulated in intestinal biopsies of patients affected by coeliac disease (CD). Combined bioinformatics analyses of miRNA expression profiles and mRNA tar...
متن کاملThe role of microRNAs in cardiovascular disease
Cardiovascular disease has become the main factor of death and birth defects in the world. There are some therapeutic structures and drugs for curative and palliative therapy of the disease, but to the aim of accessing reliable therapy or to postpone onset of disease, especially for individuals with heritable coronary artery disease in their pedigree Genetic engineering technologies are making...
متن کاملCirculating microRNAs in aging
Aging research is currently focusing on circulating functional markers that can help discriminate the mechanisms of physiological aging from those of agerelated diseases (ARDs). The cellular model of choice for this type of studies, cell senescence, has been providing highly valuable information. Senescent cells are characterized by permanent cell cycle arrest and acquisition of a senescence-as...
متن کاملExtracellular/circulating microRNAs and their potential role in cardiovascular disease.
microRNAs (miRs, miRNAs) are small non-coding RNAs that regulate hundreds of gene expression. Numerous studies have demonstrated that miRNAs are not only found intracellularly, but also detectable outside cells, including various body fluids (i.e. serum, plasma, saliva, urine, breast milk, and tears). Interestingly, ~90% of extracellular miRNAs are packaged with proteins (i.e. Ago2, HDL, and ot...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-51805-6